Hillsdale history professor Burt Folsom compares Obama in 2010 to FDR in 1938 here.   After showing that their election campaigns and policies for the first two years were very similar, Burt notes:

The results of FDR?s 1938 midterm election and Obama?s 2010 campaign
appear to be similar. Roosvelt lost 81 seats in the House and eight in
the Senate. Obama seems headed for a loss of 60+ seats in the House and
seven or eight in the Senate. 

The entire article is well worth reading.